Home Acta Virologica 2016 Acta Virologica Vol.60, No.2, p.136-142, 2016

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.60, No.2, p.136-142, 2016

Title: Detection of emerging rotavirus G12P[8] in Sonora, México
Author: G. GONZÁLEZ-OCHOA, G. de J. QUINTERO-OCHOA, P. M. CALLEJA-GARCÍA, J. A. ROSAS-RODRÍGUEZ, A. VIRGEN-ORTÍZ, P. TAMEZ-GUERRA

Abstract: Rotavirus is the most common cause of gastroenteritis in children up to five years of age worldwide. The aim of the present study was to analyze the genotypes of rotavirus strains isolated from children with gastroenteritis, after the introduction of the rotavirus vaccine in México. Rotavirus was detected in 14/100 (14%) fecal samples from children with gastroenteritis, using a commercial test kit. The viral genome was purified from these samples and used as a template in RT-PCR amplification of the VP4 and VP7 genes, followed by gene cloning and sequencing. Among the rotavirus strains, 4/14 (28.5%) were characterized as G12P[8], 2/14 (14.3%), as G12P (not typed), and 3/14 (21.42%) as G (not typed) P[8]. Phylogenetic analysis of the VP7 gene showed that G12 genotypes clustered in lineage III. Phylogenetic analysis revealed that VP4 genotype P[8] sequences clustered in lineage V, whereas other P[8] sequences previously reported in Mexico (2005–2008) clustered in different lineages. Rotavirus genotype G12 is currently recognized as a globally emerging rotavirus. To our knowledge, this is the first report of this emerging rotavirus strain G12P[8] in México. Ongoing surveillance is recommended to monitor the distribution of rotavirus genotypes and to continually reassess the suitability of currently available rotavirus vaccines.

Keywords: rotavirus; gastroenteritis; G12P[8]
Published online: 06-Jun-2016
Year: 2016, Volume: 60, Issue: 2 Page From: 136, Page To: 142
doi:10.4149/av_2016_02_136


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