Home Acta Virologica 2016 Acta Virologica Vol.60, No.2, p.151-155, 2016

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.60, No.2, p.151-155, 2016

Title: Effect of the nucleotides surrounding the start codon on the translation of foot-and-mouth disease virus RNA
Author: X. X. MA, Y. P. FENG, Y. X. GU, J. H. ZHOU, Z. R. MA

Abstract: As for the alternative AUGs in foot-and-mouth disease virus (FMDV), nucleotide bias of the context flanking the AUG2nd could be used as a strong signal to initiate translation. To determine the role of the specific nucleotide context, dicistronic reporter constructs were engineered to contain different versions of nucleotide context linking between internal ribosome entry site (IRES) and downstream gene. The results indicate that under FMDV IRES-dependent mechanism, the nucleotide contexts flanking start codon can influence the translation initiation efficiencies. The most optimal sequences for both start codons have proved to be UUU AUG1st AAC and AAG AUG2nd GAA.

Keywords: foot-and-mouth disease virus; nucleotide bias; translation initiation; dicistronic reporter; internal ribosome entry site
Published online: 06-Jun-2016
Year: 2016, Volume: 60, Issue: 2 Page From: 151, Page To: 155
doi:10.4149/av_2016_02_151


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