Acta Virologica Vol.60, No.2, p.211-213, 2016

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ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.60, No.2, p.211-213, 2016
Title: Expression of DOK1, 2, and 3 genes in HTLV-1-infected T cells
Author: T. OHSUGI, M. WAKAMIYA, S. MORIKAWA, M. FUJITA

Abstract: Human T-cell leukemia virus type 1 (HTLV-1) can cause an aggressive malignancy known as adult T-cell leukemia/lymphoma (ATLL). The Tax protein encoded by the pX region of the HTLV-1 genome appears to be a key element in the early stage of ATLL development. In this study, we examined the expression of the downstream of tyrosine kinase (DOK) family members DOK1, DOK2 and DOK3, recently reported to be tumor suppressors, in HTLV-1-transformed T cells (MT-2 and HUT-102) and TL-Om1 cells derived from ATLL leukemic cells. DOK2 and DOK3 expression was significantly reduced in MT-2, HUT-102, and TL-Om1 cells compared with their expression in uninfected T cells, and the expression of DOK3 was reduced by the induction of Tax expression in T cells.

Keywords: adult T-cell leukemia/lymphoma; downstream of tyrosine kinase 1; DOK1; DOK2; DOK3; human T-cell leukemia virus type; tax
	Published online: 06-Jun-2016
Year: 2016, Volume: 60, Issue: 2	Page From: 211, Page To: 213
doi:10.4149/av_2016_02_211
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