Journal info
Aims and Scope |
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
General Physiology and Biophysics Vol.35, No.3, p.287–298, 2016 |
||
Title: New mechanisms of vesicles migration | ||
Author: Viviana Aursulesei, Decebal Vasincu, Daniel Timofte, Lucia Vrajitoriu, Irina Gatu, Dan D. Iacob, Vlad Ghizdovat, Calin Buzea, Maricel Agop | ||
Abstract: In multicellular organisms, both health and disease are defined by means of communication patterns involving the component cells. Despite the intricate networks of soluble mediators, cells are also programed to exchange complex messages pre-assembled as multimolecular cargo of membranous structures known as extracellular vesicles (EVs). Several biogenetic pathways produce EVs with different properties able to orchestrate neighboring cell reactions or to establish an environment ripe for spreading tumor cells. Such an effect is in fact an extension of similar physiological roles played by exosomes in guiding cell migration under nontumoral tissue remodeling and organogenesis. We start with a biological thought experiment equivalent to Bénard’s experiment, involving a fluid layer of EVs adherent to an extracellular matrix, in a haptotactic gradient, then, we build and present the first Lorenz model for EVs migration. Using Galerkin’s method of reducing a system of partial differential equations to a system of ordinary differential equations, a biological Lorenz system is developed. Such a physical frame distributing individual molecular or exosomal type cell-guiding cues in the extracellular matrix space could serve as a guide for tissue neoformation of the budding pattern in nontumoral or tumoral instances. |
||
Keywords: Extracellular vesicles — Extracellular matrix space — Cell-guiding cues — Budding pattern — Bénard-Rayleigh model — Biological Lorenz system | ||
Published online: 13-Jun-2016 | ||
Year: 2016, Volume: 35, Issue: 3 | Page From: 287, Page To: 298 | |
doi:10.4149/gpb_2015048 |
||
|
download file |
|