Home HOME General Physiology and Biophysics 2016 General Physiology and Biophysics Vol.35, No.3, p.343–351, 2016

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.35, No.3, p.343–351, 2016

Title: Gender and chronological age affect erythrocyte membrane oxidative indices in citrate phosphate dextrose adenine-formula 1 (CPDA-1) blood bank storage condition
Author: Hayriye Erman, Uğur Aksu, Ahmet Belce, Pınar Atukeren, Duygu Uzun, Tamer Cebe, Ahmet D. Kansu, Remisa Gelişgen, Ezel Uslu, Seval Aydın, Ufuk Çakatay

Abstract: It is well known that in vitro storage lesions lead to membrane dysfunction and decreased number of functional erythrocytes. As erythrocytes get older, in storage media as well as in peripheral circulation, they undergo a variety of biochemical changes. In our study, the erythrocytes with different age groups in citrate phosphate dextrose adenine-formula 1 (CPDA-1) storage solution were used in order to investigate the possible effect of gender factor on oxidative damage. Oxidative damage biomarkers in erythrocyte membranes such as ferric reducing antioxidant power, pro-oxidant-antioxidant balance, protein-bound advance glycation end products, and sialic acid were analyzed. Current study reveals that change in membrane redox status during blood-bank storage condition also depends on both gender-depended homeostatic factors and the presence of CPDA-1. During the storage period in CPDA-1, erythrocytes from the male donors are mostly affected by free radical-mediated oxidative stress but erythrocytes obtained from females are severely affected by glyoxidative stress.

Keywords: Aging — Free radicals — Erythrocyte — Blood bank storage — Percoll density gradient centrifugation
Published online: 13-Jun-2016
Year: 2016, Volume: 35, Issue: 3 Page From: 343, Page To: 351
doi:10.4149/gpb_2016001


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