Home General Physiology and Biophysics 2016 General Physiology and Biophysics Vol.35, No.3, p.371–377, 2016

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Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
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General Physiology and Biophysics Vol.35, No.3, p.371–377, 2016

Title: Effect of noise stress on cardiovascular system in adult male albino rat: implication of stress hormones, endothelial dysfunction and oxidative stress
Author: Mona A. Said, Ola A. El-Gohary
Abstract: Noise pollution has been realized as an environmental stressor associated with modern life style that affects our health without being consciously aware of it. The present study investigated the effect of acute, chronic intermittent and chronic continuous exposure to noise of intensity 80–100  dB on heart rate and mean systemic arterial blood pressure in rats and the possible underlying mechanisms. Noise stress causes significant increase in heart rate, mean systemic arterial blood pressure as well as significant increase in plasma levels of corticosterone, adrenaline, noradrenaline, endothelin-1, nitric oxide and malondialdehyde with significant decrease in superoxide dismutase and these values are significantly more worse in chronic continuous exposure to noise than acute or chronic intermittent exposure. These findings suggest that noise stress has many adverse effects on cardiovascular system via increasing plasma levels of stress hormones, oxidative stress and endothelial dysfunction. These findings have major implication in the management of adverse cardiovascular reactions of people subjected to daily noise stress.
Keywords: Noise — Cardiovascular system — Stress hormones — Oxidative stress — Endothelial dysfunction
Published online: 13-Jun-2016
Year: 2016, Volume: 35, Issue: 3 Page From: 371, Page To: 377
doi:10.4149/gpb_2016003


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