Home Bratislava Medical Journal 2016 Bratislava Medical Journal Vol.117, No.6, p.355-357, 2016

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.117, No.6, p.355-357, 2016

Title: The effect of fundus resection on weight loss and ghrelin levels in rats
Author: A. Okus, B. Sevinc, O. Karahan, S. Ay, S. Civcik

Abstract: BACKGROUND: Ghrelin is a 28-amino acid peptide that is isolated mainly from the oxyntic glands of the stomach, especially fundus. Ghrelin administration, either centrally or peripherally, increases food intake and body weight in both rodents and humans. This study evaluates the effects of fundus resection and sclerosing agent injection on ghrelin level and weight loss.
MATERIAL AND METHODS: Thirty rats were divided into three groups. In group 1, NaCl was injected into the submucosal space at the gastric fundus while in Group 2, a sclerosing agent was injected into the latter site. In group 3, gastric fundus was resected. Ghrelin levels and weight were recorded.
RESULTS: In group 1, rats continued gaining weight and ghrelin levels stayed stable. In group 2, rats’ weight and ghrelin levels stayed stable and in group 3, while weight stayed stable, ghrelin levels decreased significantly.
CONCLUSION: In rats, the resection of fundus stabilizes weight gain and decreases ghrelin levels. However, in sclerotherapy, although weight gain was stabilized, there was no decrease in ghrelin levels. In humans, the effect of fundus resection on weight gain can usher in a new era of investigation (Tab. 2, Ref. 16).

Keywords: fundus resection, sclerotherapy, ghrelin
Published online: 13-Jun-2016
Year: 2016, Volume: 117, Issue: 6 Page From: 355, Page To: 357

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