Home Bratislava Medical Journal 2016 Bratislava Medical Journal Vol.117, No.7, p.367-370, 2016

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.117, No.7, p.367-370, 2016

Title: Association of interleukin 1 gene cluster and interleukin 1 receptor gene polymorphisms with ischemic heart failure
Author: M. J. Mahmoudi, M. Taghvaei, S. Harsini, A. A. Amirzargar, M. Hedayat, M. Mahmoudi, E. Nematipour, E. Farhadi, N. Esfahanian, M. Sadr, K. Nourijelyani, N. Rezaei

Abstract: BACKGROUND: Proinflammatory cytokines have been known to play a considerable part in the pathomechanisms of chronic heart failure (CHF). Given the importance of proinflammatory cytokines in the context of the failing heart, we assessed whether the polymorphisms of interleukin (IL)-1 gene cluster, including IL-1α, IL-1β, and IL-1 receptor antagonist (IL-1RA) and IL-1R gene are predictors of CHF due to ischemic heart disease.
METHODS: Forty- three patients with ischemic heart failure were recruited in this study as patients group and compared with 140 healthy unrelated control subjects. Using polymerase chain reaction with sequence-specific primers method, the allele and genotype frequency of 5 single nucleotide polymorphisms (SNPs) within the IL-1α (-889), IL-1β (-511, +3962), IL-1R (psti 1970), and IL-1RA (mspa1 11100) genes were determined.
RESULTS: The frequency of the IL-1β -511/C allele was significantly higher in the patient group compared to that in the control group (p = 0.031). The IL-1β (-511) C/C genotype was significantly overrepresented in patients compared to controls (p = 0.022).
CONCLUSIONS: Particular allele and genotype in IL-1β gene were overrepresented in patients with ischemic heart failure, possibly affecting the individual susceptibility to this disease (Tab. 1, Ref. 27).

Keywords: heart failure, single nucleotide polymorphism, interleukin-1
Published online: 12-Jul-2016
Year: 2016, Volume: 117, Issue: 7 Page From: 367, Page To: 370

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