Home Acta Virologica 2016 Acta Virologica Vol.60, No.3, p.328-332, 2016

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.60, No.3, p.328-332, 2016

Title: The synergistic antiviral effects of GSH in combination with acyclovir against BoHV-1 infection in vitro
Author: CH. YUAN, X. FU, L. HUANG, Y. MA, X. DING, L. ZHU, G. ZHU

Abstract: We have recently reported that bovine herpesvirus 1 (BoHV-1)-induced overproduction of reactive oxygen species (ROS) partially depends on NADPH oxidases (Noxs). In this study, we found that the decreased levels of main intracellular non-enzymatic antioxidant glutathione (GSH) during BoHV-1 infection also contributed to ROS production. Exogenous GSH administration dramatically inhibited BoHV-1 replication, indicating the critical role of decreased GSH for BoHV-1 replication. Interestingly, GSH synergistically enhanced the antiviral effects of acyclovir (ACV) against BoHV-1 infection in vitro. This study not only illuminates the effect of GSH on BoHV-1 infection but also provides evidence that pharmacological modulation of GSH-mediated ROS production in combination with specific antiviral drugs is a viable therapeutic approach to fighting virus infection.

Keywords: BoHV-1; ROS; GSH; Noxs
Published online: 13-Sep-2016
Year: 2016, Volume: 60, Issue: 3 Page From: 328, Page To: 332
doi:10.4149/av_2016_03_328


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