Home Bratislava Medical Journal 2016 Bratislava Medical Journal Vol.117, No.9, p.543-546, 2016

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.117, No.9, p.543-546, 2016

Title: Phenytoin accelerates tendon healing in a rat model of Achilles tendon rupture
Author: B. Hajipour, A. M. Navali, S. Ali Mohammad Zadeh Taher, G. Mousavi, M. Gahvechi Akbari, T. Maleki Miyandoab, L. Roshangar, B. Mohammadi Saleh, T. Asvadi Kermani, F. Moutab Laleh, M. Ghabili


INTRODUCTION: Tendons are vulnerable to various types of acute or chronic injures. Different methods have been investigated to achieve better healing. Phenytoin is a drug which could stimulate fibroblasts to produce collagen. This experimental study was performed to assess the effect of phenytoin on tendon healing in a rat model of tendon rupture.
METHODS: Thirty healthy rats were divided into 3 groups, 1) Sham group; 2) Tendon rupture; 3) Tendon rupture+phenytoin (100 mg/kg intraperitoneally) for 21 days. On 21st day after tendon injury, the rats were anesthetized and tendon tissue was sampled for studying by light and electron microscopy.
RESULTS: Qualitative and quantitative microscopic comparisons of the repair tissues of both groups were made on the 21st day. The results obtained from light and electron microscopy studies showed that tendon tissue healing was significantly better in phenytoin group compared to the control group (p < 0.05).

CONCLUSIONS: Systemic administration of phenytoin may have a positive effect on tendon healing by increasing fibroblast quantity, fibrillar collagen synthesis, vascularity, and suppressing inflammation (Tab. 2, Ref. 25).

Keywords: tendon, healing, phenytoin, rat
Published online: 21-Sep-2016
Year: 2016, Volume: 117, Issue: 9 Page From: 543, Page To: 546

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