Home Bratislava Medical Journal 2016 Bratislava Medical Journal Vol.117, No.10, p.562-570, 2016

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2


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Bratislava Medical Journal Vol.117, No.10, p.562-570, 2016

Title: Conservative versus invasive treatment in hypertrophic obstructive cardiomyopathy: an echocardiography study
Author: T. Honek, J. Krejci, J. Machal, L. Groch, J. Sitar, J. Meluzin, L. Spinarova


AIM AND METHODS: The aim of our study was to compare the development of echocardiographic parameters and functional status of patients with hypertrophic obstructive cardiomyopathy (HOCM) treated conservatively (n = 41) or by alcohol septal ablation (ASA; n = 39).
RESULTS: Left ventricular outflow tract gradient (LVOTG) decreased in the first year by 53.7±36.4 mmHg in ASA group versus 5.5±47.1 mmHg in conservatively treated group (p<0.001), in the third year by 53.1±41.4 mmHg versus 23.9±42.7 mmHg (p = NS) and in the fifth year, the reduction of LVOTG was 52.1±44.5 mmHg in ASA group and 3.0±63.2 mmHg in conservatively treated group (p<0.05).

Change in NYHA class in the first year was –1.1±0.4 versus 0.1±0.5, in the third year –1.0±0.6 versus 0.1±0.4 and in the fifth year –0.8±0.5 versus 0.1±0.4 (all p<0.001).
CONCLUSION: Our results showed for the first time that decline of LVOTG after ASA creates a favorable left ventricle remodeling and leads to significant improvement of functional status of HOCM patients in comparison with conservative treatment (Tab. 3, Fig. 2, Ref. 42).

Keywords: hypertrophic obstructive cardiomyopathy, alcohol septal ablation, conservative treatment, invasive treatment, echocardiography
Published online: 07-Nov-2016
Year: 2016, Volume: 117, Issue: 10 Page From: 562, Page To: 570

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