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Bratislava Medical Journal Vol.117, No.10, p.614-618, 2016 |
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Title: The anti-inflammatory and antioxidant effects of thymoquinone on ceruleine induced acute pancreatitis in rats | ||
Author: A. Dur, H. Kose, A. Kocyigit, O. Kocaman, M. Ismayilova, F. C. Sonmez | ||
Abstract: INTRODUCTION: The aim of this study is to investigate the potential antioxidant and anti-inflammatory effects of thymoquinone (TQ) on ceruleine induced acute pancreatitis. RESULTS: The increased serum amylase, lipase levels and histopathological scoring of pancreatic tissue showed that acute pancreatitis was present in both groups. Furthermore, serum IL-1β level was significantly reduced in TQ administered group (p < 0.05). Although serum TAC level was high and TOS level was low, those changes were not statistically significant. Nevertheless, OSI index, which was driven from TOS/TAC, was significantly low in TQ groups (p < 0.05). Although TQ partially ameliorated the acute pancreatitis in terms of histopathological evaluations, the main effect of it was brought about by reducing the hemorrhage in acute pancreatitis (p < 0.05). |
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Keywords: acute pancreatitis, thymoquinone, inflammation, rat | ||
Published online: 07-Nov-2016 | ||
Year: 2016, Volume: 117, Issue: 10 | Page From: 614, Page To: 618 | |
doi:10.4149/BLL_2016_119 |
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