Home Bratislava Medical Journal 2016 Bratislava Medical Journal Vol.117, No.10, p.583-586, 2016

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.117, No.10, p.583-586, 2016

Title: Chronic hypoxia increases fetoplacental vascular resistance in rat placenta perfused with blood
Author: P. Kafka, O. Vajnerova, V. Hampl

Abstract: BACKGROUND: Chronic hypoxia elevates vascular resistance on the fetal side of the placenta. However, when a low-viscosity perfusate is used, the increase in resistance caused by chronic hypoxia is relatively small (12 mmHg). In the present study, we tested the hypothesis that perfusion with more viscous fluid (blood) will reveal more substantial effect of chronic hypoxia.
METHODS: Using an isolated, dually perfused rat placenta perfused at a constant flow rate with homologous blood, perfusion pressure on the fetal side was measured. Then, the relationship between perfusion pressure and flow (P/Q) was determined.
RESULTS: Fetoplacental vascular resistance was increased by chronic hypoxia (10 % O2) during the last third of gestation. This was observed when the placentas were perfused with a low viscosity Krebs solution and more enhanced when perfused with blood. Nevertheless, we found no clear advantage for using blood instead of Krebs solution to study the effects of hypoxia on the fetoplacental vasculature. The elevation of fetoplacental vascular resistance caused by chronic hypoxia was at least partly resistant to acute reoxygenation.
CONCLUSION: Using blood for the perfusion of the isolated rat placenta does not confer any clear methodological advantage over using Krebs solution (Tab. 2, Fig. 2, Ref. 21).

Keywords: placenta, blood perfusion, chronic hypoxia, pressure/flow relationship, intrauterine growth restriction
Published online: 07-Nov-2016
Year: 2016, Volume: 117, Issue: 10 Page From: 583, Page To: 586

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