Home HOME Neoplasma 2017 Neoplasma Vol.64, No.1, p.136-139,2017

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Neoplasma Vol.64, No.1, p.136-139,2017

Title: Predictors of survival in patients with brain metastases from gastric cancer
Author: D. RADES, T. BARTSCHT, S. E. SCHILD

Abstract:

This study aims to identify predictors of survival and contribute to treatment personalization in patients with brain metastases from gastric cancer. Twelve patients received whole-brain radiotherapy (WBRT), four stereotactic radiosurgery and six neurosurgery plus WBRT. Treatment regimen, age, gender, Eastern Cooperative Oncology Group (ECOG) performance score, tumor site, number of brain metastases, extra-cranial metastases and interval between cancer diagnosis and brain metastases were evaluated for survival. On univariate analyses, more intensive treatment (p=0.003), ECOG-score 0-1 (p<0.001), cardiac location (p=0.025) and single brain metastasis (p=0.023) were associated with better survival. On multivariate analysis, ECOG-score maintained significance (p<0.001).

Patients with all three positive factors on univariate analysis had a 12-month survival rate of 100%, patients with three negative factors a 3-month survival rate of 0%. Predictors of survival were identified that can guide physicians selecting personalized treatment approaches for patients with brain metastases from gastric cancer.



Keywords: gastric cancer, cardiac cancer, brain metastases, radiotherapy, survival
Published online: 10-Jan-2017
Year: 2017, Volume: 64, Issue: 1 Page From: 136, Page To: 139
doi:10.4149/neo_2017_117


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