Home HOME Acta Virologica 2016 Acta Virologica Vol.60, No.4, p.404-409, 2016

Journal info

Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

Impact Factor = 1.82

Aims and Scope
Abstracted and Indexed

Select Journal

Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Acta Virologica Vol.60, No.4, p.404-409, 2016

Title: Discovery of natural mouse serum derived HIV-1 entry inhibitor(s)
Author: M. WEI, Y. CHEN, J. XI, S. RU, M. JI, D. ZHANG, Q. FANG, B. TANG

Abstract: Among rationally designed human immunodeficiency virus 1 (HIV-1) inhibitors, diverse natural factors have showed as potent anti-HIV activity in human blood. We have discovered that the boiled supernatant of healthy mouse serum could suppress HIV-1 entry, and exhibited reduced inhibitory activity after trypsin digestion. Further analysis demonstrated that only the fraction containing 10–25 K proteins could inhibit HIV-1 mediated cell-cell fusion. These results suggest that the 10–25 K protein(s) is novel natural HIV-1 entry inhibitor(s). Our findings provide important information about novel natural HIV entry inhibitors in mouse serum.

Keywords: HIV-1; HIV-1 entry; natural inhibitor; mouse serum
Published online: 07-Dec-2016
Year: 2016, Volume: 60, Issue: 4 Page From: 404, Page To: 409

download file

© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.