Acta Virologica Vol.60, No.4, p.404-409, 2016

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Acta Virologica Vol.60, No.4, p.404-409, 2016
Title: Discovery of natural mouse serum derived HIV-1 entry inhibitor(s)
Author: M. WEI, Y. CHEN, J. XI, S. RU, M. JI, D. ZHANG, Q. FANG, B. TANG

Abstract: Among rationally designed human immunodeficiency virus 1 (HIV-1) inhibitors, diverse natural factors have showed as potent anti-HIV activity in human blood. We have discovered that the boiled supernatant of healthy mouse serum could suppress HIV-1 entry, and exhibited reduced inhibitory activity after trypsin digestion. Further analysis demonstrated that only the fraction containing 10–25 K proteins could inhibit HIV-1 mediated cell-cell fusion. These results suggest that the 10–25 K protein(s) is novel natural HIV-1 entry inhibitor(s). Our findings provide important information about novel natural HIV entry inhibitors in mouse serum.

Keywords: HIV-1; HIV-1 entry; natural inhibitor; mouse serum
	Published online: 07-Dec-2016
Year: 2016, Volume: 60, Issue: 4	Page From: 404, Page To: 409
doi:10.4149/av_2016_04_404
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