Home Bratislava Medical Journal 2016 Bratislava Medical Journal Vol.117, No.12, p.702-709, 2016

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.117, No.12, p.702-709, 2016

Title: Vitamin D status in apparently healthy medication-free Slovaks: Association to blood pressure, body mass index, self-reported smoking status and physical activity
Author: K. Sebekova, Z. Krivosikova, M. Gajdos, L Podracka


BACKGROUND: Vitamin D plays a role in protecting against chronic degenerative diseases. Slovak adults present one of the highest cardiovascular mortality rates among 27 EU countries.
OBJECTIVES: We asked whether the 25(OH)D3 status in apparently healthy medication-free Slovaks deteriorates upon ageing, and in the presence of cardiometabolic risk factors.
METHODS: We studied the impact of blood pressure, overweight/obesity, smoking, and physical activity on 25(OH)D3 levels determined using RIA method in 578 (5–81 years old) subjects.
RESULTS: The average level of 25(OH)D3 was 36±17 ng/ml. A proportion of 15 % of participants were 25(OH)D3‑deficient (≤20 ng/ml), 26 % presented insufficient (20-to-30 ng/ml), and 59 % satisfactory (> 30 ng/ml) levels.

Neither mean 25(OH)D3 levels, nor the prevalence of hypovitaminosis D showed age dependence. Physically active normotensive non-smokers presented the highest (41±19 ng/ml), and their smoking counterparts with elevated BP the lowest 25(OH)D3 levels (30±12 ng/ml).
CONCLUSION: In apparently healthy medication-free Slovaks the prevalence of hypovitaminosis D is high. Vitamin D status does not deteriorate in course of healthy ageing. Physical activity, normotension, and non-smoking status are associated with favorable vitamin D status while low 25(OH)D3 levels are associated with multiple cardiometabolic risk factors. Further studies in subjects at high cardiovascular risk are needed to elucidate the potential association of hypovitaminosis D with high cardiovascular mortality in Slovak adults (Tab. 1, Fig. 4, Ref. 42).

Keywords: vitamin D, blood pressure, smoking, physical activity, body mass index.
Published online: 28-Dec-2016
Year: 2016, Volume: 117, Issue: 12 Page From: 702, Page To: 709

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