Home Neoplasma 2017 Neoplasma Vol.64, No.2, p.167-174, 2017

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.64, No.2, p.167-174, 2017

Title: A comprehensive analysis of candidate gene signatures in oral squamous cell carcinoma
Author: X. LI, R. SUN, X. GENG, S. WANG, D. ZEN, J. PEI, J. YANG, Y. FAN, H. JIANG, P. YANG, C. LI

Abstract: This study aimed to unravel the molecular mechanism of oral squamous cell carcinoma (OSCC). With microarray dataset GSE30784, differentially expressed genes (DEGs) were identified between OSCC and control samples. The DEGs overlapped with genes obtained from online database MalaCards were determined as OSCCDEG, followed by Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. A total of 5177 up-regulated and 6081 down-regulated DEGs were identified between OSCC and control. Out of the DEGs, 451 genes were overlapped with the 704 genes gained from MalaCards and regarded as “OSCCDEG”. Up-regulated OSCCDEG were associated with cell cycle pathway, while down-regulated OSCCDEG were linked to ErbB pathway. ANGPT1, ANGPT2 and 3 hub proteins (EGFR, HSP90AA1, RB1) in the PPI network were associated with the survival rates of several tumors. The largest network module with the hub protein EGFR was associated with positive regulation of cell communication. The second largest module with the hub node FN1 was related to angiogenesis. For the third network module in connection with DNA metabolism, the hub protein was PCNA. ErbB and cell cycle pathways were crucial for OSCC. EGFR, FN1, PCNA, ANGPT1 and ANGPT2 might be potential biomarkers for OSCC. These findings help provide guidelines for treating OSCC.

Keywords: oral squamous cell carcinoma, network module, differentially expressed genes, protein-protein interaction, gene ontology
Published online: 14-Mar-2017
Year: 2017, Volume: 64, Issue: 2 Page From: 167, Page To: 174

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