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Neoplasma Vol.64, No.2, p.262-268, 2017 |
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Title: Prognostic value of apoptosis inducing factor in uveal melanoma | ||
Author: V. KRASNIK, A. FURDOVA, Z. SVETLOSAKOVA, D. KOBZOVA, H. GERGISAKOVA, L. FEKETEOVA, M. SVETLOSAK, A. BARTA, P. BABAL | ||
Abstract: In malignant tumors including uveal melanoma there is a continuous effort in search for additional and relevant factors with predictive value and possible therapeutic indications. In the present work we evaluated the 5-year mortality in a group of patients with surgically treated uveal melanoma and its relation to selected demographic, clinical and histopathological parameters, including the expression of apoptosis inducing factor (AIF) in the neoplastic tissue. Moderate and strong expression of AIF in tumor cells also correlated with less favorable prognosis. Confocal microscopy proved colocalization of AIF with mitochondrial marker in neoplastic cells. |
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Keywords: uveal melanoma, apoptosis inducing factor, prognosis | ||
Published online: 14-Mar-2017 | ||
Year: 2017, Volume: 64, Issue: 2 | Page From: 262, Page To: 268 | |
doi:10.4149/neo_2017_213 |
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