Home Neoplasma 2017 Neoplasma Vol.64, No.2, p.299-304, 2017

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.64, No.2, p.299-304, 2017

Title: Cytotoxic T lymphocyte-associated antigen 4 rs231775 polymorphism and osteosarcoma
Author: N. Bilbao-Aldaiturriaga, A. PATINO-Garcia, I. Martin-Guerrero, A. Garcia-Orad

Abstract: Systematic reviews on osteosarcoma have concluded that CTLA4 rs231775 AA genotype influences risk for the disease in the Chinese population. Remarkably, rs231775 shows different frequencies in different human populations. Therefore, it would be interesting to know whether this SNP is related to the risk of osteosarcoma in other populations. The present study aimed to evaluate the association between rs231775 and the susceptibility of osteosarcoma in the Spanish population. We performed an updated meta-analysis including a total of 538 cases and 623 controls.
The genotypic association analyses showed that the CTLA4 rs231755 was associated with osteosarcoma susceptibility in the Spanish population. When meta-analysis was performed, the results displayed that CTLA4 rs231775 AA genotype was associated with the risk of developing osteosarcoma in all analyzed populations (OR=2.07; 95% CI: 1.48-2.89).
The rs231775 AA genotype could be considered as a susceptibility marker in osteosarcoma

Keywords: CTLA4, rs231775, +49A/G and osteogenic sarcoma
Published online: 14-Mar-2017
Year: 2017, Volume: 64, Issue: 2 Page From: 299, Page To: 304

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