Home CONTACT Acta Virologica 2017 Acta Virologica Vol.61, No.1, p.32-38, 2017

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.61, No.1, p.32-38, 2017

Title: The effect of Isoprinosine treatment on persistent infection of Balb/c mice infected with murine gammaherpesvirus 68
Author: O. JANÍČKOVÁ, L. ANČICOVÁ, K. BRIESTENSKÁ, J. MISTRÍKOVÁ

Abstract: We demonstrated the positive effect of Isoprinosine treatment on persistent infection of Balb/c mice with murine gammaherpesvirus 68 (MHV-68). Increased number of leukocytes, increased percentage of neutrophils, elevated levels of virus-neutralizing (VN) antibodies, reduced number of atypical lymphocytes and reduced virus titers were detected in the examined organs after a 14-day treatment. The positive effect of Isoprinosine therapy vanished after 120–150 days. After this interval, we demonstrated lower numbers of leukocytes, lower levels of VN antibodies and an increased number of atypical lymphoid monocytes in the Isoprinosine-treated group. Immunological parameters correlated with increased titers of virus in all investigated organs. Evidence of immunostimulation was demonstrated by lower incidence of tumor formation (7.5%) in the group of MHV-infected and Isoprinosine-treated mice in comparison to group without Isoprinosine treatment (17.5%). The presented results showed that Isoprinosine therapy had a positive impact on persistent infection of mice with MHV-68, but this effect was time-limited. The improvement of the investigated parameters lasted for five months only. Our presented results confirmed that each treatment with Isoprinosine should be repeated and must be long-term in some chronic infections.

Keywords: MHV-68; Isoprinosine; immunity; reactivation of latent virus; tumors
Published online: 28-Feb-2017
Year: 2017, Volume: 61, Issue: 1 Page From: 32, Page To: 38
doi:10.4149/av_2017_01_32


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