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Bratislava Medical Journal Vol.118, No.2, p.80-84, 2017 |
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Title: Effects of sevoflurane on apoptosis, BDNF and cognitive functions in neonatal rats | ||
Author: A. B. Ozer, S. Ceribasi, A. O. Ceribasi, I. Demirel, M. K. Bayar, B. Ustundag, A. Ileri, O. L. Erhan | ||
Abstract: OBJECTIVE: To evaluate the early and late effects of sevoflurane on the neonatal brain. BDNF levels in cerebral cortex were higher in the Group CE than in the Group CL and SL (p < 0.05). There was a significant negative correlation between serum BDNF and cortex BDNF levels (p = 0.003, r = –0.425). Cortex caspase 3 levels were significantly higher in the Groups SE and SL than in the Group CE and CL (p < 0.05). There was no significant difference between the groups in the terms of open arm index, locomotor activity and Morris water test. |
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Keywords: anesthesia, neonatal, apoptosis, BDNF | ||
Published online: 16-Feb-2017 | ||
Year: 2017, Volume: 118, Issue: 2 | Page From: 80, Page To: 84 | |
doi:10.4149/BLL_2017_017 |
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