Home Bratislava Medical Journal 2017 Bratislava Medical Journal Vol.118, No.2, p.95-100, 2017

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.118, No.2, p.95-100, 2017

Title: Melatonin: a hepatoprotective agent against radioiodine toxicity in rats
Author: A. M. Barlas, M. Sadic, H. I. Atilgan, Y. M. Bag, A. K. Onalan, N. Yumusak, M. Senes, V. Fidanci, M. R. Pekcici, M. Korkmaz, K. Kismet, G. Koca


OBJECTIVES: The aim of the current study was to investigate the possible radioprotective effects of melatonin against hepatic radioiodine (RAI) toxicity.
METHODS: Thirty-six rats were randomly divided into three groups: untreated control (Group 1); oral radioiodine (RAI, 111 MBq) administrated rats (Group 2), and melatonin group (oral RAI and daily intraperitoneal injection of 12 mg/kg melatonin-Group 3). In the third group, melatonin administration was started two days before and continued for five days after RAI administration. Twenty-four hours after the administration of the last dose of melatonin, liver samples were taken for biochemical and histopathological evaluation.
RESULTS: Oxidative stress parameters demonstrated that melatonin treatment decreased the tissue malondialdehyde (MDA), advanced the oxidation protein products (AOPP) levels, and increased the total-SH (sulphydryl) levels when compared with RAI group. The differences were statistically significant between these groups for all parameters (p < 0.05).

The histopathological damage in the melatonin-treated group was significantly less than the damage in RAI group (p < 0.05 for all pathological parameters).
CONCLUSION: The results of this study demonstrated that melatonin reduced the harmful effects of RAI treatment on the liver. Anti-inflammatory and antioxidant activities are likely to be involved in the mechanism underlying the radio-protective effects of melatonin (Tab. 3, Fig. 1, Ref. 30).

Keywords: melatonin, radioiodine, liver, oxidative stress, histopathology
Published online: 16-Feb-2017
Year: 2017, Volume: 118, Issue: 2 Page From: 95, Page To: 100

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