Home CONTACT Neoplasma 2017 Neoplasma Vol.64, No.3, p.437-443, 2017

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.64, No.3, p.437-443, 2017

Title: Effect of small and radical surgical injury on the level of different populations of circulating tumor cells in the blood of breast cancer patients
Author: E. V. Kaigorodova, N. A. Tarabanovskaya, M. N. Staheeva, O. E. Savelieva, L. A. Tashireva, E. V. Denisov, V. M. Perelmuter

Abstract: Circulating tumor cells (CTCs) constitute a heterogeneous population. Some tumor cells are cancer stem cells (CSCs), while others are in the process of the epithelial-mesenchymal transition (EMT); however, most CTCs are neither stem cells nor in the EMT. This prospective study of 22 patients with nonspecific-type invasive carcinoma of the breast identified different populations of CTCs by flow cytometry in the blood of patients before biopsy, after biopsy and after surgical tumor removal without neoadjuvant chemotherapy. The results showed that minor surgical injury (biopsy) was accompanied by a significant increase in the blood levels of CTCs without signs of the EMT or stemness (Epcam+CD45-CD44-CD24-Ncadh-) and CTCs with signs of stemness and without signs of the EMT (Epcam+CD45-CD44+CD24-Ncadh-). Our results suggest that minor surgical injury to a tumor contributes to the release of CTCs into the bloodstream, including a population of stem cells.

Keywords: breast cancer, circulating tumor cells (CTCs), cancer stem cells (CSCs), epithelial-mesenchymal transition (EMT), flow cytometry
Published online: 12-May-2017
Year: 2017, Volume: 64, Issue: 3 Page From: 437, Page To: 443

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