Home Acta Virologica 2017 Acta Virologica Vol.61, No.2, p.212-216, 2017

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.61, No.2, p.212-216, 2017

Title: Genetic variability of the S1 subunit of enteric and respiratory bovine coronavirus isolates
Author: S. VILČEK, A. JACKOVÁ, M. KOLESÁROVÁ, M. VLASÁKOVÁ

Abstract: Bovine coronavirus (BCoV) is considered an important pathogen in cattle worldwide. It is a causative agent of enteric and respiratory diseases of cattle. The S1 subunit of the viral S glycoprotein is responsible for virus binding to host-cell receptors, induction of neutralizing antibody and hemagglutinin activity. The entire S1 genomic region (2304 bp) of two enteric bovine coronavirus isolates from Austria, one respiratory and one enteric isolate from Slovakia were analyzed at the genetic level. The comparative analysis of those four isolates revealed 97.1–98.6% similarity at the nucleotide and 95.6–98.6% at the amino acid level. No differences between enteric and respiratory isolates were observed at the genetic level. The isolates were clustered in the phylogenetic tree with European isolates independently of their enteric or respiratory origin.

Keywords: bovine coronavirus; S1 subunit; molecular characterization; phylogenetic analysis
Published online: 12-Apr-2017
Year: 2017, Volume: 61, Issue: 2 Page From: 212, Page To: 216
doi:10.4149/av_2017_02_12


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