Home Bratislava Medical Journal 2017 Bratislava Medical Journal Vol.118, No.4, p.223-227, 2017

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

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Bratislava Medical Journal Vol.118, No.4, p.223-227, 2017

Title: Effect of sodium aescinate treatment on PCOS rat model with insulin resistance
Author: L. Chen, L. M. Hu, Y. F. Wang, H. Y. Yang, X. Y. Huang, W. Zhou, H. X. Sun

Abstract: BACKGROUND: Recent studies indicated that insulin resistance may contribute to the pathogenesis of polycystic ovary syndrome (PCOS); however, the specific mechanism is still unclear.
OBJECTIVE: To investigate the effect of sodium aescinate (SA) on PCOS-IR rat models.
METHODS: Sixty rats were randomly divided into the five groups: un-treated rats (n = 12), PCOS-IR group (n = 12), PCOS-IR group plus 50 mg/kg SA (n = 12), PCOS-IR group plus 10 mg/kg SA (n = 12), PCOS-IR group plus 150 mg/kg metformin (n = 12). On day 21, rats were sacrificed, and H(and)E staining was performed for histopathologic examination of the ovaries; moreover, the serum level of follicle-stimulating hormone (FSH), testosterone, and luteotropic hormone (LH) were measured, and the expression as well as phosphorylation of PI3K, Akt and Gsk-3β were examined using western blot assay.
RESULTS: High dosage of SA treatment improved the morphological features of the ovaries in PCOS rats, and also induced significant decrease in serum expression of testosterone and LH/FSH ratio and significant decrease in the expression of p-PI3K, p-Akt and p-Gsk-3β.
CONCLUSION: Our results demonstrated that SA treatment could alleviate the symptom of PCOS in rat model through regulating the PI3K/Akt/GSK3-β pathway (Fig. 4, Ref. 22).

Keywords: sodium aescinate, polycystic ovary syndrome, insulin resistance, PI3K, AKT, GSK3-β
Published online: 02-May-2017
Year: 2017, Volume: 118, Issue: 4 Page From: 223, Page To: 227
doi:10.4149/BLL_2017_044


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