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FOR AUTHORS Bratislava Medical Journal 2017 Bratislava Medical Journal Vol.118, No.4, p.228-232, 2017
FOR AUTHORS Bratislava Medical Journal 2017 Bratislava Medical Journal Vol.118, No.4, p.228-232, 2017
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Bratislava Medical Journal Vol.118, No.4, p.228-232, 2017 |
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| Title: Protective effects of diltiazem and tadalafil on shock wave-induced kidney injury in rats | ||
| Author: G. Ozmerdiven, B. A. Vuruskan, O. Kaygisiz, H. Vuruskan | ||
| Abstract: BACKGROUND: We aimed to compare the protective effects of tadalafil and diltiazem on renal histology after ischemia and reperfusion injury in a rat model of shock wave lithotripsy. METHODS: A total of 40 adult, male Sprague-Dawley rats were randomized into four groups as follows; control group (group C), group S (SWL + nephrectomy), group T (SWL + tadalafil given before nephrectomy) and group D (SWL + diltiazem given before nephrectomy). Both kidneys were evaluated regarding tubular damage, peritubular fibrosis and heat shock protein-70 (HSP-70) immune-expression of glomeruli, cortical and medullar collector tubules on light microscopy. RESULTS: HSP-70 levels of cortical and medullar collector tubules, tubular damage and peritubular fibrosis scores were decreased in group T compared with group S. Similarly, HSP-70 immunostaining levels on cortical and medullar collector tubules, tubular damage and peritubular fibrosis scores were decreased in group D compared with group S. No significant difference was detected between group D and group T for all parameters. CONCLUSION: As a result, shock waves induced renal cell damage due to increment of HSP-70 levels, morphological irregularity in tubules and increased peritubular fibrosis. Tadalafil and diltiazem had beneficial effects in decreasing renal tissue damage which was caused by SWL (Tab. 2, Fig. 6, Ref. 29). |
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| Keywords: diltiazem, ischemia-reperfusion injury, heat shock protein, shock wave lithotripsy, renal tubules, tadalafil | ||
| Published online: 02-May-2017 | ||
| Year: 2017, Volume: 118, Issue: 4 | Page From: 228, Page To: 232 | |
| doi:10.4149/BLL_2017_045 |
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