Home Neoplasma 2017 Neoplasma Vol.64, No.4, p.485-493, 2017

Journal info

6 times a year.
Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

Published in English

Editorial Info
Abstracted and Indexed
Submission Guidelines

Select Journal

Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Neoplasma Vol.64, No.4, p.485-493, 2017

Title: Antioxidant potential of essential oil from Lavandula angustifolia in in vitro and ex vivo cultured liver cells
Author: K. Kozics, A. Srancikova, E. Sedlackova, E. Horvathova, M. Melusova, V. Melus, Z. Krajcovicova, M. Sramkova

Abstract: Lavender is a commonly used herb in traditional medicine in Asia and Europe. It has been reported to be an effective medical plant in treating inflammation, depression and stress, thanks to its sedative and anxiolytic action, thrombotic, and antimicrobial properties. In the present study we investigated the protective effects of essential oil from Lavandula angustifolia (LO) against hydrogen peroxide and tert-butyl hydroperoxide -induced DNA damage. Also the effects of LO on the levels of enzymatic and non-enzymatic antioxidants (SOD-superoxide dismutase, GPx-glutathione peroxidase, GSH-glutathione) were evaluated in in vitro (human hepatoma cell line HepG2) and in ex vivo (freshly isolated rat hepatocytes) systems. The results showed that the oxidant-induced DNA lesions were significantly reduced in both systems pre-treated with the Lavandula angustifolia. The observed DNA-protective activity could be explained by both elevation of GPx activity in cells pre-treated with LO and antioxidant activity of LO.

Keywords: Lavandula angustifolia, HepG2, primary hepatocytes, oxidative stress, antioxidant enzymes
Published online: 11-Jul-2017
Year: 2017, Volume: 64, Issue: 4 Page From: 485, Page To: 493

download file

© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.