Home HOME Neoplasma 2017 Neoplasma Vol.64, No.4, p.526-534, 2017

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.64, No.4, p.526-534, 2017

Title: miR-361-5p suppresses lung cancer cell lines progression by targeting FOXM1
Author: X. W. Hou, X. Sun, Y. Yu, H. M. Zhao, Z. J. Yang, X. Wang, X. C. Cao

Abstract: Lung cancer is the most common type of cancer and the leading cause of death in worldwide. MicroRNAs are known to be key players in a variety of biological processes, including tumorigenesis. In present study, we investigated the effect of miR-361-5p on lung cancer progression. We found that miR-361-5p was down-regulated in lung cancer. Overexpression of miR-361-5p suppressed lung cancer proliferation and invasion. Mechanistically, FOXM1 was identified as a direct target of miR-361-5p. Furthermore, miR-361-5p inhibits EMT-like phenotype through down-regulation of FOXM1 expression in lung cancer cells. In conclusion, our results indicated that miR-361-5p acts as a tumor suppressor in lung cancer.

Keywords: miR-361-5p, FOXM1, EMT, lung cancer
Published online: 11-Jul-2017
Year: 2017, Volume: 64, Issue: 4 Page From: 526, Page To: 534
doi:10.4149/neo_2017_406


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