Neoplasma Vol.64, No.4, p.526-534, 2017
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| Title: miR-361-5p suppresses lung cancer cell lines progression by targeting FOXM1 |
| Author: X. W. Hou, X. Sun, Y. Yu, H. M. Zhao, Z. J. Yang, X. Wang, X. C. Cao |
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Abstract: Lung cancer is the most common type of cancer and the leading cause of death in worldwide. MicroRNAs are known to be key players in a variety of biological processes, including tumorigenesis. In present study, we investigated the effect of miR-361-5p on lung cancer progression. We found that miR-361-5p was down-regulated in lung cancer. Overexpression of miR-361-5p suppressed lung cancer proliferation and invasion. Mechanistically, FOXM1 was identified as a direct target of miR-361-5p. Furthermore, miR-361-5p inhibits EMT-like phenotype through down-regulation of FOXM1 expression in lung cancer cells. In conclusion, our results indicated that miR-361-5p acts as a tumor suppressor in lung cancer.
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| Keywords: miR-361-5p, FOXM1, EMT, lung cancer |
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Published online: 11-Jul-2017
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| Year: 2017, Volume: 64, Issue: 4 |
Page From: 526, Page To: 534 |
doi:10.4149/neo_2017_406
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