Neoplasma Vol.64, No.4, p.579-587, 2017
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| Title: miR-215 promotes cell migration and invasion of gastric cancer cell lines by targeting FOXO1 |
| Author: Y. Zang, T. Wang, J. Pan, F. Gao |
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Abstract: Gastric cancer is one of the most common malignant tumor worldwide and has high morbidity and mortality. microRNAs are small, non-coding RNAs which play critical roles in the post-transcriptional regulation of gene expression. In this current study, we used qRT-PCR to detect miR-215 and FOXO1 expression level in 50 paired gastric cancer tissues and found that miR-215 was frequently overexpressed and FOXO1 was down-regulated in GC cancer tissues. Clinicopathological analysis showed that miR-215 expression level was correlated with the progression of tumor invasion and TNM stage. Additionally, transwell invasion assay showed that miR-215 promoted the migration and invasion of gastric cancer cells. We found that miR-215 decreased FOXO1 expression by directly binding to the 3’-untranslated region (UTR) of FOXO1. These results suggest that miR-215 promotes cell migration and invasion of gastric cancer by targeting FOXO1. Therefore, this study provides a promising therapeutic strategy for treating gastric cancer.
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| Keywords: gastric cancer, miR-215, FOXO1, migration, invasion |
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Published online: 11-Jul-2017
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| Year: 2017, Volume: 64, Issue: 4 |
Page From: 579, Page To: 587 |
doi:10.4149/neo_2017_412
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