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Bratislava Medical Journal Vol.118, No.5, p.288-291, 2017 |
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Title: Apoptosis of colon cancer cells under the effect of geldanamycin derivate | ||
Author: F. Kosova, Z. Kasar, I. Tuglu, F. Ozdal Kurt, S. Gok, Z. Ari, T. Imren | ||
Abstract: AIM: The apoptotic effect of geldanamycin derivative may be important for the colorectal cancer therapy. The mechanisms of apoptosis require understanding of the behavior of colon cancer cell line Colo-205 which mimics colon adenocarcinoma. Therefore, the effect of IC50 dose of 17-allylamino-17-demethoxygeldanamycin (17-AAG) on the colon cancer cells in vitro was studied for its anti-apoptotic activity. Our results indicated that the application of 17-AAG on Colo-205 cells showed anticancer effect by the apoptosis due to alteration of apoptotic genes. |
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Keywords: colon cancer, 17-AAG, apoptosis, RT-PCR, in vitro | ||
Published online: 15-May-2017 | ||
Year: 2017, Volume: 118, Issue: 5 | Page From: 288, Page To: 291 | |
doi:10.4149/BLL_2017_058 |
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