Home Bratislava Medical Journal 2017 Bratislava Medical Journal Vol.118, No.5, p.302-309, 2017

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

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Bratislava Medical Journal Vol.118, No.5, p.302-309, 2017

Title: A comprehensive guide to telocytes and their great potential in cardiovascular system
Author: I. Kucybala, P. Janas, S. Ciuk, W. Cholopiak, W. Klimek-Piotrowska, M. K. Holda

Abstract: Telocytes, a recently discovered type of interstitial cells, have a very distinctive morphology – the small cell body with long extensions, named telopodes. In our review, apart from introducing general aspects of telocytes, we focus on properties, functions and future potential of those cells in cardiovascular system. However, physiological functions of telocytes in cardiovascular system are still regarded as quite enigmatic. Previous studies claim that they play a role in organogenesis and regeneration, bioelectrical signalling, mechanoelectrical coupling, anti-oxidative protection, angiogenesis and regulation of blood flow. As well, they are presumably connected with the presence of blood-myocardium barrier and proper organisation of extracellular matrix. Moreover, there exists a significant link between the quantity of telocytes in tissue and numerous cardiovascular diseases such as: myocardial infarction, cardiomyopathies, systemic sclerosis, heart failure, atrial fibrillation, isolated atrial amyloidosis, myxomatous valve degeneration and hyperplastic consequences of vascular injury. Thanks to their unique properties, telocytes might be a breakthrough in treatment of cardiovascular diseases, as they may be effective in reversing effects of myocardial infarction. Telocytes also may play a major role in tissue engineering – they might be the key factor in creating stable and efficient vascular network in larger synthetic tissues or organs (Tab. 1, Fig. 3, Ref. 53).

Keywords: telocytes, heart, blood vessels, cardiovascular system, cardiovascular diseases, regenerative medicine
Published online: 15-May-2017
Year: 2017, Volume: 118, Issue: 5 Page From: 302, Page To: 309
doi:10.4149/BLL_2017_059


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