Home Endocrine Regulations 2004 Endocrine Regulations Vol.38, p.143-149, 2004

Journal info

Quarterly, 50 pp. per issue 
Founded: 1967
ISSN 1210-0668
E-ISSN 1336-0329

Published in English

Aims and Scope
Editorial Info
Submission Guidelines

Select Journal

Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Endocrine Regulations Vol.38, p.143-149, 2004

Author: Jozef Rovensky J, Zofia Radikova, Richard Imrich, Ondrej Greguska, Milan Vigas, Ladislav Macho

Abstract: Objectives. Gonadal and adrenal steroids were shown to affect multiple immune processes including inflammatory response. These effects were documented, specifically, through an influence on local productions of cytokines and the functions of synovial cells at the site of inflammatory processes. The aim of this study was to investigate the levels of selected hormones in synovial fluid of knee joints of patients with rheumatoid arthritis (RA) and with osteoarthrosis (OS, control group). Methods. The concentrations of cortisol (CORT), 17-ß-estradiol (ES), dehydroepiandrosterone (DHEA), testosterone (TE), progesterone (PRG), and aldosterone (ALD) were determined in plasma and synovial fluid. Results. Significant positive correlations between the levels in plasma and synovial fluids were observed in hormones ES, PRG, TE, DHEA and ALD. In most hormones, the levels in synovial fluids were similar as in plasma; however, the content of ALD was higher in synovial fluid as compared to plasma. Higher levels of ES (in females), DHEA (in males), and ALD were observed in plasma and synovial fluids of RA patients as compared to OS patients. After adjustment to age, no significant RA vs. OS difference was noted in ES, TE, DHEA, PRG, and CORT in plasma and synovial fluid. Age-adjusted ALD concentration tended to be higher in synovial fluid of RA patients as compared to OS patients. The ratio of ES/TE concentrations in synovial fluid was significantly higher in male RA patients compared to OS group. Also the ES/CS and ES/DHEA ratios in synovial fluid were elevated in RA patients in comparison to controls. Conclusions. These results demonstrated the prevalence of pro-inflammatory hormones in synovial fluid of RA patients, suggesting the possible role of these steroid hormones in inflammatory processes.

Keywords: Steroid hormones – Synovial fluid – Plasma – Human subjects – Rheumatoid arthritis – Osteoarthrosis
Year: 2004, Volume: 38, Issue: Page From: 143, Page To: 149

download file

© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.