Home Neoplasma 2017 Neoplasma Vol.64, No.5, p.655-665, 2017

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.64, No.5, p.655-665, 2017

Title: Mechanisms regulating radiosensitivity of glioma stem cells
Author: Y. Liu, Y. Shen, T. Sun, W. Yang

Abstract: Malignant glioblastoma (GBM) has become a very common and difficult brain tumor given its low cure rate and high recurrence rate. GBMs are resistant to treatments because glioma stem cells (GSCs)/glioma-initiating cells (GICs), a specific subpopulation of GBM, possess properties of tumor stem cells, such as unlimited proficiency, self-renewal, differentiation and resistance to chemotherapy and radiotherapy, and exhibit a very strong DNA repair capability. Radiotherapy has become a preponderant treatment, and researchers have found many significant tumor microenvironmental factors and valuable signaling pathways regulating the GSC radioresistance, including NOTCH, Wnt/β-catenin, Hedgehog, STAT3, and PI3K/AKT/mTOR. Therefore, we seek to boost GSC radiosensitivity through activating or inactivating pathways alone or together to eliminate the likely source of glioma and prolong survival of patients.

Keywords: glioma stem cells, radiosensitivity, signaling pathways
Published online: 31-Aug-2017
Year: 2017, Volume: 64, Issue: 5 Page From: 655, Page To: 665
doi:10.4149/neo_2017_502
Price: 26.40 €






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