Home Neoplasma 2017 Neoplasma Vol.64, No.5, p.770-777, 2017

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.64, No.5, p.770-777, 2017

Title: The miR-93 promotes proliferation by directly targeting PDCD4 in hepatocellular carcinoma
Author: H. Huang, X. Wang, C. Wang, L. Zhuo, S. Luo, S. Han

Abstract:

Hepatocellular carcinoma (HCC) is the second leading cause of cancer mortality worldwide. Although advances have made in treatment of HCC, the overall survival rate remains low and the molecular pathogenesis of HCC is still poorly understood. The purpose of this study was to explore the molecular pathogenesis of HCC. A total of 89 patients were involved in the study. MicroRNA-93 (miR-93) was aberrantly up-regulated in HCC tissues as determined by qRT-PCR. The high level of miR-93 was closely associated with larger tumor size (p < 0.05) and poor overall survival (p < 0.05).

In in vitro and in vivo assays, we demonstrated that high miR-93 levels enhanced cell growth of HCC. The luciferase activity assay showed that PDCD4 was a direct target of miR-93 and its expression was down-regulated by miR-93. Re-expression of PDCD4 inversely correlated with the level of miR-93 and attenuated the miR-93-induced promotion of cell growth in HCC. Taken together, our data indicate that miR-93 may function as an oncogenic factor in HCC, and promotes HCC cell proliferation by targeting PDCD4.



Keywords: growth, hepatocellular carcinoma, miR-93, PDCD4
Published online: 31-Aug-2017
Year: 2017, Volume: 64, Issue: 5 Page From: 770, Page To: 777
doi:10.4149/neo_2017_516
Price: 19.20 €






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