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Neoplasma Vol.64, No.5, p.795-802, 2017 |
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Title: Combination of LINE-1 hypomethylation and RASSF1A promoter hypermethylation in serum DNA is a non-invasion prognostic biomarker for early recurrence of hepatocellular carcinoma after curative resection | ||
Author: Z. J. Liu, Y. Huang, L. Wei, J. Y. He, Q. Y. Liu, X. Q. Yu, Z. L. Li, J. Zhang, B. Li, C. J. Sun, W. B. Liang, A. M. Sun, Y. Qin | ||
Abstract: Hepatocarcinogenesis, a multistep process, involves not only genetic mutations but also epigenetic alterations. Widespread of global DNA hypomethylation is accompanied with specific regional hypermethylation especially at tumor suppressor genes’ promoters. The aim of this study is to determine the efficacy of combined DNA methylation analysis of a global DNA methylation marker – LINE-1 and a tumor suppressor gene highly associated with the malignancy of HCC- RASSF1A in serum as a novel prognostic marker for diagnosis of early recurrence after curative resection. Besides, significant correlation was detected between RASSF1A promoter hypermethylation and lymph nodes metastasis (p=0.045). |
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Keywords: hepatocellular carcinoma, RASSF1A hypermethylation, LINE-1 hypomethylation, prognosis | ||
Published online: 31-Aug-2017 | ||
Year: 2017, Volume: 64, Issue: 5 | Page From: 795, Page To: 802 | |
doi:10.4149/neo_2017_519 |
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