Acta Virologica Vol.61, No.3, p.240-251, 2017

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.61, No.3, p.240-251, 2017
Title: To keep the host alive – the role of viral Bcl-2 proteins
Author: P. POLČIC, M. MENTEL, G. GAVURNÍKOVÁ, I. BHATIA-KIŠŠOVÁ

Abstract: Apoptosis, an intrinsic cellular pathway that eliminates unwanted cells from multicellular organisms, represents an important mechanism for protection against viral infections. When cells infected by viruses get recognized by immune cells, apoptosis is triggered in the infected cells. Among the many regulators of apoptosis involved in this process, a family of proteins homologous to oncogene Bcl-2 plays a central role. Their concerted activities converge to permeabilization of mitochondrial membranes and activation of apoptotic pathways in the presence of diverse apoptotic signals, including virus infection. In the genomes of many viruses, genes encoding for homologues of antiapoptotic proteins of Bcl-2 family can be found. These proteins, collectively referred to as vBcl-2 proteins, inhibit apoptosis in infected cells at the different stages of virus life cycle to enable the virus to complete its replication and to spread.

Keywords: apoptosis; vBcl-2; Bcl-2 family; autophagy; virus
	Published online: 28-Aug-2017
Year: 2017, Volume: 61, Issue: 3	Page From: 240, Page To: 251
doi:10.4149/av_2017_302
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