Home CONTACT Acta Virologica 2017 Acta Virologica Vol.61, No.3, p.240-251, 2017

Journal info


Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

Impact Factor = 1.82

Aims and Scope
Editorial Info

Abstracted and Indexed
Submission Guidelines

Select Journal







Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Acta Virologica Vol.61, No.3, p.240-251, 2017

Title: To keep the host alive – the role of viral Bcl-2 proteins
Author: P. POLČIC, M. MENTEL, G. GAVURNÍKOVÁ, I. BHATIA-KIŠŠOVÁ

Abstract: Apoptosis, an intrinsic cellular pathway that eliminates unwanted cells from multicellular organisms, represents an important mechanism for protection against viral infections. When cells infected by viruses get recognized by immune cells, apoptosis is triggered in the infected cells. Among the many regulators of apoptosis involved in this process, a family of proteins homologous to oncogene Bcl-2 plays a central role. Their concerted activities converge to permeabilization of mitochondrial membranes and activation of apoptotic pathways in the presence of diverse apoptotic signals, including virus infection. In the genomes of many viruses, genes encoding for homologues of antiapoptotic proteins of Bcl-2 family can be found. These proteins, collectively referred to as vBcl-2 proteins, inhibit apoptosis in infected cells at the different stages of virus life cycle to enable the virus to complete its replication and to spread.

Keywords: apoptosis; vBcl-2; Bcl-2 family; autophagy; virus
Published online: 28-Aug-2017
Year: 2017, Volume: 61, Issue: 3 Page From: 240, Page To: 251
doi:10.4149/av_2017_302


download file



© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.