Home Bratislava Medical Journal 2017 Bratislava Medical Journal Vol.118, No.6, p.347-354, 2017

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564

 

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Bratislava Medical Journal Vol.118, No.6, p.347-354, 2017

Title: Therapeutic effects of melatonin and quercetin in improvement of hepatic steatosis in rats through supression of oxidative damage
Author: M. Esrefoglu, A. Cetin, E. Taslidere, H. Elbe, B. Ates, O. E. Tok, M. S. Aydin
Abstract: BACKGROUND: Non-alcoholic steatohepatitis, a cause of cirrhosis, is characterized by fatty infiltration of the liver, inflammation, hepatocellular damage and fibrosis. The aim of the present study was to investigate the effects of melatonin and quercetin on CCl4–induced steatosis characterized by fatty infiltration of the liver, inflammation, hepatocellular damage and fibrosis.
METHODS: Rats were divided into 5 groups: Ethanol, Olive oil, CCl4, CCl4+Melatonin (CCl4+Mel), CCl4+Quercetin. Rats were sacrificed and livers were removed for being evaluated by histopathological, immunohistochemical and biochemical methods.
RESULTS: In CCI4 group, vacuolization, vascular congestion, haemorrhage, necrosis, and inflammatory infiltration were identified. The mean tissue MDA level was increased, whereas GSH level and SOD and CAT activities were decreased in comparison with ethanol and olive oil groups. MDA levels were decreased in CCI4+Quercetin and CCI4+Mel groups versus CCI4 group. CAT activity of CCI4+Mel group was higher than that of CCI4 and CCI4+Quercetin groups. The mean tissue GSH level of CCI4+Mel group versus CCI4 group was significantly increased.
CONCLUSIONS: By the means of histopathological examination, we suggest that both agents are beneficial against necrotic and apoptotic cell death during steatosis. Thus, melatonin and quercetin might be beneficial in the improvement of hepatic steatosis by supporting conventional therapy in humans (Tab. 1, Fig. 5, Ref. 53).
Keywords: antioxidant, melatonin, quercetin, liver
Published online: 22-Jun-2017
Year: 2017, Volume: 118, Issue: 6 Page From: 347, Page To: 354
doi:10.4149/BLL_2017_066


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