Home CONTACT Acta Virologica 2017 Acta Virologica Vol.61, No.3, p.316-323, 2017

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Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

Impact Factor = 1.82

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Acta Virologica Vol.61, No.3, p.316-323, 2017

Title: Hepatitis C virus induces oxidative stress and DNA damage by regulating DNAPKCs, ATM, ATR and PARP mediated signaling and guards cell from cancerous condition by upregulating RB, P53 and downregulating VEGF
Author: U. SAEED, Z. Z. PIRACHA, S. MANZOOR

Abstract: Hepatitis C virus is responsible for liver damage and various metabolic disorders. HCV infections promote oxidative stress and cause damage to macromolecules. The aim of our study was to design a preliminary study with establishment of HCV genotype 3a infectivity assay in order to determine DNA damage in Huh-7 cell line at 72 hours post inoculation. Quantitative expression levels of COX-2 and GSR (oxidants and antioxidants), DNAPKCs, ATM, ATR and PARP (DNA damage and repair genes), RB and P53 (tumor suppressor genes) and VEGF (angiogenesis marker) were observed via real time PCR. Our findings revealed 1.533 fold upregulated expression of COX-2. The expression level of GSR was increased by1.27 fold and VEGF expression decreased by 0.367 fold. Thus, preventing cells to enter cancerous phase.

Keywords: hepatitis C virus; DNA damage and repair; cyclooxygenase-2; glutathione reductase; DNAPKCs; VEGF; P53; RB
Published online: 28-Aug-2017
Year: 2017, Volume: 61, Issue: 3 Page From: 316, Page To: 323
doi:10.4149/av_2017_310


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