Home Acta Virologica 2017 Acta Virologica Vol.61, No.3, p.341-346, 2017

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ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.61, No.3, p.341-346, 2017

Title: Photodynamic Effect of some Phthalocyanines on Enveloped and Naked Viruses
Author: L. Nikolaeva-Glomb, L. Mukova, N. Nikolova, V. Kussovski, L. Doumanova, V. Mantareva, I. Angelov, D. Wöhrle, A. S. Galabov

Abstract: Activity of three photosensitizing phthalocyanine derivatives was tested for photodynamic inactivation towards two coated and two non-enveloped viruses – bovine viral diarrhea virus (BVDV), influenza virus A(H3N2), poliovirus type 1 (PV-1) and human adenovirus type 5 (HAdV5). In the case of coated viruses, a combination of virucidal and irradiation effects was registered by octa-methylpyridyloxy-substituted Ga phthalocyanine (Ga8) toward BVDV, whereas tetra-methylpyridyloxy-substituted Ga phthalocyanine (Ga4) revealed a marked photoinactivation only. No such effect was observed towards influenza A virus. In contrast, the photoinactivating potential of Ga4 and Ga8 marked very high values on naked viruses, especially on HAdV5, at which both the virucidal as well as the irradiation effects became combined.

Keywords: phthalocyanine; photodynamic inactivation; virus
Published online: 28-Aug-2017
Year: 2017, Volume: 61, Issue: 3 Page From: 341, Page To: 346
doi:10.4149/av_2017_313


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