Home Bratislava Medical Journal 2017 Bratislava Medical Journal Vol.118, No.7, p.405-407, 2017

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

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Bratislava Medical Journal Vol.118, No.7, p.405-407, 2017

Title: The impact of using different doses of progesterone on memory performance
Author: A. Roozbehi, M. T. Sharafi, F. Karimi, A. M. Kamali

Abstract:

OBJECTIVE: Progesterone is a sex hormone and its receptors are expressed throughout the hippocampus. This study was aimed at evaluating the effects of different doses of progesterone on memory.
METHODS: Male rats were arbitrarily assigned to nine groups, namely Group I: control, Group II: control–cannula, Group III received 0.5 μl of saline by cannula, Groups IV , V, VI, VII and VIII received progesterone in doses of 0.5, 1, 1.5, 2, and 3 μg/ 0.5 μl by cannula, respectively. Group IX received 0.5 μl almond oil by cannula. Memory performance was tested in form of passive avoidance task.
RESULTS: Our results indicated that progesterone at doses of 1.5 and 2 µg (p < 0.05) significantly increased the memory performance while at a dose of 3 µg (p < 0.05), it significantly decreased memory as compared to the control group.

CONCLUSION: The current study revealed that the influence of progesterone on memory is related to its dose (Fig. 1, Ref. 25).



Keywords: progesterone, hippocampus, passive avoidance task, memory
Published online: 24-Jul-2017
Year: 2017, Volume: 118, Issue: 7 Page From: 405, Page To: 407
doi:10.4149/BLL_2017_079


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