Home Bratislava Medical Journal 2017 Bratislava Medical Journal Vol.118, No.7, p.417-422, 2017

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

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Bratislava Medical Journal Vol.118, No.7, p.417-422, 2017

Title: Effect of different doses of pregabalin on skeletal muscle ischaemia-reperfusion injury in rats
Author: L. Ozturk, H. T. Dogan, A. Kilicarslan, M. E. Aydin, A. Ozer, H. Demirtas, Y. Kilic, E. Iriz, A. Kucuk, A. C. Bayraktar, M. Kavutcu, M. Arslan

Abstract:

AIM/INTRODUCTION: Analgesic, anti-inflammatory and anti-apoptotic effects of pregabalin have been shown previously. In this study, we investigated the protective effect of different doses of pregabalin on skeletal muscle IR injury in rats.
MATERIALS AND METHODS: 24 rats were randomly divided into 4 groups (Control, Ischaemia-Reperfusion (IR), IR-Pregabalin 50 mg, IR-Pregabalin 200 mg). Following IR, serum Ischemia Modified Albumin (IMA) and tissue Paraoxonase (PON) were studied and gastrocnemius muscle tissue was removed for histopathologic examination.
RESULTS: Interstitial inflammation was higher in the IR group than in the control and Pregabalin 200 mg groups (p = 0.037, p = 0.037, respectively). Congestion was higher in the IR group than in the control, Pregabalin 50 and 200 mg groups (p = 0.001, p = 0.004, p = 0.004, respectively). PON was lower in the IR group than in the Control, Pregabalin 50 and 200 mg groups (p = 0.001, p = 0.007, p = 0.015, respectively). IMA was higher in the IR group than in the Control, Pregabalin 50 and 200 mg groups (p < 0.0001, all).

CONCLUSION: We think that administration of pregabalin, more prominent at 200 mg, can reverse the injury that occurs in the skeletal muscle of IR-induced rats. Pregabalin can be safely used for analgesia in cases of IR (Tab. 2, Fig. 9, Ref. 41).



Keywords: hind limb ischemia reperfusion, pregabalin, histopathology, IMA, PON
Published online: 24-Jul-2017
Year: 2017, Volume: 118, Issue: 7 Page From: 417, Page To: 422
doi:10.4149/BLL_2017_081


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