Home FOR AUTHORS Acta Virologica 2017 Acta Virologica Vol.61, No.3, p.372-376, 2017

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.61, No.3, p.372-376, 2017

Title: Two mice models for transferability of zoonotic bacteria via tick vector
Author: B. SALLAY, T. VACULOVÁ, M. DERDÁKOVÁ, V. RUSŇÁKOVÁ TARAGEĽOVÁ, E. ŠPITALSKÁ, Ľ. ŠKULTÉTY

Abstract: Spotted fever and typhus-related diseases caused by rickettsiae, Lyme borreliosis induced by spirochetes from Borrelia burgdorferii sensu lato complex, and Q fever evoked by Coxiella burnetii, are important zoonoses occurring worldwide. In order to study the pathogenesis of these infections, the efficacy of vaccines from the perspective of protection against the pathogens, pathogen – pathogen interactions during co-infections or pathogen-vector-host interrelationship, a suitable animal model should be established. In this study, we evaluated two mouse models – the C3H/N and Balb/c strains for susceptibility to infection and ability to transmit the pathogens via tick vector and to reveal the potential interactions between various bacterial tick-borne agents. Our results indicated that the C3H/N and Balb/c mice are well-accepted models of B. afzelii infection. However, they are not suitable for interaction studies with R. helvetica since the animals did not acquire rickettsiemia and do not transmit Rickettsia sp. to feeding ticks.

Keywords: animal model; pathogen transferability; tick vector; Ixodes ricinus; Coxiella burnetii; Rickettsia helvetica; Borrelia afzelii
Published online: 28-Aug-2017
Year: 2017, Volume: 61, Issue: 3 Page From: 372, Page To: 376
doi:10.4149/av_2017_319


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