Home CONTACT Acta Virologica 2017 Acta Virologica Vol.61, No.3, p.377-390, 2017

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.61, No.3, p.377-390, 2017

Title: Coxiella burnetii immunogenic proteins as a basis for new Q fever diagnostic and vaccine development
Author: C. Gerlach, Ľ. Škultéty, K. Henning, H. Neubauer, K. Mertens

Abstract: Coxiella burnetii is the etiological agent of the zoonosis Q fever, which can cause an acute or a chronic, life-threatening disease in humans. It presents a highly stable cell form, which persists in the environment and is transmitted via contaminated aerosols. Ruminants are considered as the main reservoir for human infections but are usually asymptomatic. Subclinical infection in these animals and the occurrence of serologically negative shedders hamper the identification of infected animals with the currently used diagnostic techniques. This suboptimal sensitivity limits reliable identification of infected animals as well as the well-timed implementation of countermeasures. This review summarizes compounds, focusing on C. burnetii seroreactive proteins, which were discovered in recent immunoproteomic studies. We analyzed these proteins regarding their localization, function, frequency of citation, differences seen in various host species as well as sensitivity and specificity. Finally, proteins useful for the development of new diagnostic test systems as well as subunit vaccines were discussed.

Keywords: Coxiella burnetii; proteomic analysis; immunoreactive proteins; specificity; sensitivity; serological diagnostics
Published online: 28-Aug-2017
Year: 2017, Volume: 61, Issue: 3 Page From: 377, Page To: 390
doi:10.4149/av_2017_320


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