Home Bratislava Medical Journal 2017 Bratislava Medical Journal Vol.118, No.8, p.453-459, 2017

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

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Bratislava Medical Journal Vol.118, No.8, p.453-459, 2017

Title: The effect of sulforaphane on oxidative stress and inflammation in rats with toxic hepatitis induced by acetaminophene
Author: E. Dokumacioglu, H. Iskender, M. S. Aktas, B. Hanedan, A. Dokumacioglu, T. M. Sen, A. Musmul

Abstract: OBJECTIVE: The aim of the present study was to reveal the possible effect of sulforaphane on oxidative stress and inflammation in rats liver with toxic hepatitis induced by acetaminophene.
BACKGROUND: Sulforaphane is a compound with high antioxidant properties. Acetaminophen, which is a para-aminophenol derivative, can lead to fatal hepatic necrosis with direct hepatotoxic effects at high doses.
METHODS: Thirty six male Sprague-Dawley rats were randomly divided into four groups. Control group (n = 9) was fed with standard rat chow and water for 3 days. Group APAP (n = 9) received a single dose acetaminophen 1 g/kg by oral gavage in addition to standard chow and water. Group SFN (n = 9) received sulforaphane 500 μg/kg by oral gavage in addition to standard chow and water for 3 days. Group APAP+SFN (n = 9) received sulforaphane 500 μg/kg and a single dose acetaminophen 1 g/kg by oral gavage in addition to standard chow and water. Acetaminophen was administered three hours after SFN administration.
RESULTS: Neopterin, MDA, AST, ALT and CRP levels of group APAP were significantly increased compared to control group. GSH level of group APAP was significantly lower than in the control group.
CONCLUSION: Sulforaphane is a protective agent against acetaminophen-induced liver damage and it can be added in the treatment protocol (Tab. 1, Fig. 5, Ref. 51).

Keywords: acetaminophen, lipid peroxidation, neopterin, oxidative stress, sulforaphane
Published online: 31-Aug-2017
Year: 2017, Volume: 118, Issue: 8 Page From: 453, Page To: 459
doi:10.4149/BLL_2017_088


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