Home Bratislava Medical Journal 2017 Bratislava Medical Journal Vol.118, No.8, p.467-471, 2017

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

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Bratislava Medical Journal Vol.118, No.8, p.467-471, 2017

Title: eNOS and XRCC4 VNTR variants contribute to formation of nicotine dependence and/or schizophrenia
Author: S. Pehlivan, M. A. Uysal, P. C. Aydin, M. Pehlivan, A. F. Nursal, H. Yavuzlar, S. Kurnaz, U. Sever, F. K. Yavuz, S. Uysal, N. Aydin

Abstract: BACKGROUND: This study aimed to evaluate whether VNTR variants in the Endothelial Nitric Oxide Synthase (eNOS) and the XRCC4 gene play any role in nicotine dependence (ND) and/or Schizophrenia+ND (Sch+ND) ethiopathogenesis.
METHODS: Present study included 100 individuals with ND, 60 patients with Sch+ND, and 70 healthy controls. These variants were analyzed using PCR.
RESULTS: The cases with ND had higher eNOS VNTR-BB genotype than the healthy control subjects (p = 0.001). eNOS-AA genotype was lower in cases with Sch+ND and ND groups compared to the controls (p = 0.001, p = 0.001, respectively). eNOS-B allele was found significantly more frequently in Sch+ND group compared to the controls (p = 0.001). eNOS-A allele was significantly lower in ND group than the controls (p = 0.001). XRCC4-ID genotype was more common in the ND group than the control group (p = 0.001) as heterozygosity disadvantage. XRCC4-DD genotype was more common in the Sch+ND group compared to the controls (p = 0.035). The frequency of XRCC4-I allele was lower in the Sch+ND group compared to the controls (p = 0.012).
CONCLUSIONS: Our results showed that eNOS and XRCC4 VNTR variants might play a potential role in Sch+ND and/or ND pathophysiology (Tab. 2, Ref. 48).

Keywords: schizophrenia, endothelial nitric oxide synthase, XRCC4, nicotine dependence
Published online: 31-Aug-2017
Year: 2017, Volume: 118, Issue: 8 Page From: 467, Page To: 471
doi:10.4149/BLL_2017_090


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