Home General Physiology and Biophysics 2017 General Physiology and Biophysics Vol.36, No.4, p.423–430, 2017

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Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
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General Physiology and Biophysics Vol.36, No.4, p.423–430, 2017

Title: Research on the effect of formononetin on photodynamic therapy in K562 cells
Author: Dan Sun, Yao Lu, Su-juan Zhang, Kai-ge Wang, Zhe Sun
Abstract: At the present time, many cancer patients combine some forms of complementary and alternative medicine therapies with their conventional therapies. The most common choice of these therapies is the use of antioxidants. Formononetin is presented in different foods. It has a variety of biological activities including antioxidant and anti-cancer properties. On account of its antioxidant activity, formononetin might protect cancer cells from free radical damage in photodynamic therapy (PDT) during which reactive oxygen species (ROS) production was stimulated leading to irreversible tumor cell injury. In this study, the influence of formononetin on K562 cells in PDT was demonstrated. The results showed that formononetin supplementation alone did not affect the lipid peroxidation, DNA damage and apoptosis in K562 cells. It increases the lipid peroxidation, DNA damage and apoptosis in K562 cells induced by PDT. The singlet oxygen quencher sodium azide suppresses the apoptosis induced by PDT with formononetin. In conclusion, formononetin consumption during PDT increases the effectiveness of cancer therapy on malignant cells. The effect of antioxidants on PDT maybe was determined by its sensitization ability to singlet oxygen.
Keywords: Formononetin — Reactive oxygen species — Photodynamic therapy — Sodium azide — Leukemia K562
Published online: 13-Sep-2017
Year: 2017, Volume: 36, Issue: 4 Page From: 423, Page To: 430
doi:10.4149/gpb_2017004


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