Home General Physiology and Biophysics 2017 General Physiology and Biophysics Vol.36, No.4, p.431–441, 2017

Journal info

Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

Aims and Scope
Editorial Info
Abstracting and Indexing
Submission Guidelines

Select Journal

Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

General Physiology and Biophysics Vol.36, No.4, p.431–441, 2017

Title: Purinergic regulation of brain catecholamine neurotransmission: In vivo electrophysiology and microdialysis study in rats
Author: Eliyahu Dremencov, Lubica Lacinova, Gunnar Flik, Joost H. A. Folgering, Thomas I. F. H. Cremers, Ben H. C. Westerink

Abstract: It was previously reported that adenosine-2A (A2A) receptors interact with dopamine-2 (D2) receptors on a molecular level. The aim of the current study was to investigate the functional output of this interaction. In vivo microdialysis was used to assess the effects of an antagonist of A2A receptors, ZM 241385, and an antagonist of D2 receptors haloperidol, either alone or in combination, on brain catecholamine levels. It was found that ZM 241385 did not alter catecholamine levels by its own, but potentiated haloperidol-induced dopamine and norepinephrine release in the nucleus accumbens and prefrontal cortex, respectively. In vivo electrophysiology was used to assess the effect of an agonist (CGS 216820) and an antagonist (ZM 241385) of A2A receptors on the excitability of dopamine and norepinephrine neurons. It was found that CGS 216820 dose-dependently inhibited dopamine and norepinephrine neurons and ZM 241385 reversed this inhibition. In conclusion, those A2A receptors modulate brain catecholamine transmission, and this modulation is mediated, at least in part, via the regulation of excitability of norepinephrine and dopamine neurons. The ability of antagonists of A2A receptors to potentiate the effect of haloperidol on brain norepinephrine and dopamine levels may enhance its clinical efficacy as an antipsychotic drug.

Keywords: Adenosine-2A receptors — Antipsychotic drugs — Dopamine-2 receptors —alpha-1/2-adrenergic receptors — Electrophysiology —Microdialysis
Published online: 13-Sep-2017
Year: 2017, Volume: 36, Issue: 4 Page From: 431, Page To: 441

download file

© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.